CLEMSON, SC (AP) — Isaac Brown ran for a career-high 151 yards and a touchdown in the fourth quarter as Louisville beat No. 11 Clemson for the first time, 33-21 on Saturday night.

Cardinals quarterback Tyler Sough made a wild leap for a score and Brock Travelstead matched his career high with four field goals as Louisville (6-4, 4-2 Atlantic Coast Conference) qualified for a bowl game and went 0-8 in his career against the Tigers (6-2, 5-1).

The Cardinals seriously dented Clemson’s hopes of playing for an ACC title and making the College Football Playoff. The Tigers were among four undefeated ACC teams when the week began and now must get outside help for the season in its final month.

Should put the Cardinals ahead for good in the second quarter with a 4-yard burst, finishing with a fumble in the end zone for a 10-7 lead.

Travelstead, who was 9-of-15 on field goals this season, made kicks of 21, 42, 40 and 49 yards to match his career high of two made last season.

And when the Tigers pulled to within 26-14 midway through the final period, Brown ended any hope of a comeback with a 45-yard touchdown run.

It was Brown’s fourth game of 100 or more yards and he has 847 yards this season, one shy of Heisman Trophy winner and two-time NFL MVP Lamar Jackson’s school freshman record of 960 of meters established in 2015.

Louisville, which started the season in the Top 25 and is off to a 3-0 start, has lost three of its last five games and was an upset to continue that slide at Clemson.

Clemson came in averaging 42 points and 490 yards per game in its 6-1 start. But it was Louisville that continually generated yards and kept the Tigers from putting up points.

Louisville found every opening in the Tigers’ defense and took advantage of every mistake.

Louisville blocked Clemson’s 49-yard field goal late in the second quarter and passed on Travelstead’s second field goal to lead 17-7 at halftime — the first time Clemson had led at halftime since the loss to Georgia.

The Cardinals blocked another field goal attempt in the fourth quarter after Clemson’s drive stalled at the Louisville 7.

Clemson tailback Phil Mafah had 171 yards and two TDs in the fourth quarter.

Take away

Louisville: The Cardinals’ defense has been the weak point during their 2-3 slide after a 3-0 start, allowing nearly 33 points a contest over their last five games. But Louisville had more than enough to stuff the Tigers, including on a fourth-and-1 in the third quarter when Clemson was desperate to keep a drive alive.

Clemson: The Tigers dug themselves out of a hole after losing to Georgia in the season opener before bouncing back against Louisville. Even winning their last four games does not guarantee they will play for a league title.

Further on

Louisville is off before going to Stanford on Nov. 16.

Clemson plays at Virginia Tech next Saturday.

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