Refreshed and rejuvenated.

That’s exactly how it is San Francisco 49ers they should feel it coming off their bye week. It should have them locked in and ready for Week 10 against the Tampa Bay Buccaneers. The 49ers will have a massive rest advantage over the Buccaneers.

Not only are they coming off a week without a game, but the Buccaneers are coming off an overtime loss on Monday Night Football. The Buccaneers likely won’t be in top shape, especially compared to the 49ers. Should be a pretty easy win for the 49ers. They come for a week without a match and

But what’s really going to make this one pretty easy is because of the 49ers’ offense. The 49ers will have offensive success against the Buccaneers. A strength of the 49ers’ offense is a weakness of the Buccaneers’ defense. That strength of the 49ers is the use of 21 personnel (two running backs, one tight end). They’ve used him on 39.5 percent of snaps this season, according to Next Gen Statistics.

The 49ers averaged 7.2 yards per game from 21 personnel, the most in a season in the Kyle Shanahan era (since 2017). The Buccaneers have matched 21 personnel with the base defense (four defensive backs) in 65.9 percent of games this season, slightly more often than the league average (62.6 percent).

They have allowed 212 yards and a touchdown on 24 carries when opposing offenses have used 21 personnel this season. That translated to 8.8 yards per carry, the most in the NFL. So the 49ers don’t have to change anything with their offense. It’s like matching a negative with a positive. The 49ers face the perfect defense, which fits incredibly favorably for them.

Not to mention Christian McCaffrey could be back for this game. It will be a field day for the 49ers on offense against the Buccaneers. The 49ers are 4-1 in their last five games after a bye week. Their record will most likely improve to 5-1 given the favorable circumstances.

Tampa Bay is coming off a tough week and will now have to face a rested 49ers team that has the formula to decimate their defense. Sunday will be a long day for the Buccaneers.