Ototoxicity, characterized by hearing loss and other auditory disturbances, is a significant adverse effect associated with various drugs, such as aminoglycosides, loop diuretics, and especially cisplatin, which is widely used in chemotherapy. This condition not only lowers the quality of life of affected individuals, but also represents a considerable public health challenge. The widespread impact of drug-induced ototoxicity underscores the urgent need for effective preventive and therapeutic strategies. Recent studies have highlighted the complex interplay of genetic, molecular, and environmental factors that contribute to ototoxicity, but the precise mechanisms remain poorly understood. Current research efforts are focused on elucidating these mechanisms and identifying potential therapeutic targets. However, there is a notable gap in translating these findings into clinical practice, requiring further investigation into innovative prevention and treatment approaches.

This research topic aims to improve our understanding of the mechanisms underlying drug-induced ototoxicity and to identify potential therapeutic targets for intervention. This effort aspires to facilitate the development of effective clinical solutions that can prevent or mitigate the adverse auditory effects of ototoxic drugs. By addressing these objectives, research seeks to contribute to improved therapeutic strategies and patient outcomes, ultimately reducing the burden of ototoxicity on individuals and healthcare systems.

To gather more information on prevention and therapeutic intervention in drug-induced ototoxicity, we welcome articles that address, but are not limited to, the following topics:
– Investigate the morphological changes and pathological basis of drug-induced ototoxicity.
– Explore the biological mechanisms and pathways, including inflammation, immune responses, and cytokine signaling, that contribute to ototoxicity.
– Assess the protective effects and underlying mechanisms of drugs designed to mitigate ototoxicity, identifying new therapeutic targets.
– Review of existing literature on drugs with known ototoxicity-mitigating properties and their mechanisms of action.

Key words: ototoxicity, hearing loss, drug-induced toxicity, aminoglycosides, cisplatin, therapeutic targets, protective agents, hearing health

Important note: All contributions to this research topic must fall within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to refer an out-of-scope manuscript to a more appropriate section or journal at any stage of peer review.

Ototoxicity, characterized by hearing loss and other auditory disturbances, is a significant adverse effect associated with various drugs, such as aminoglycosides, loop diuretics, and especially cisplatin, which is widely used in chemotherapy. This condition not only lowers the quality of life of affected individuals, but also represents a considerable public health challenge. The widespread impact of drug-induced ototoxicity underscores the urgent need for effective preventive and therapeutic strategies. Recent studies have highlighted the complex interplay of genetic, molecular, and environmental factors that contribute to ototoxicity, but the precise mechanisms remain poorly understood. Current research efforts are focused on elucidating these mechanisms and identifying potential therapeutic targets. However, there is a notable gap in translating these findings into clinical practice, requiring further investigation into innovative prevention and treatment approaches.

This research topic aims to improve our understanding of the mechanisms underlying drug-induced ototoxicity and to identify potential therapeutic targets for intervention. This effort aspires to facilitate the development of effective clinical solutions that can prevent or mitigate the adverse auditory effects of ototoxic drugs. By addressing these objectives, research aims to contribute to improved therapeutic strategies and patient outcomes, ultimately reducing the burden of ototoxicity on individuals and healthcare systems.

To gather more information on prevention and therapeutic intervention in drug-induced ototoxicity, we welcome articles that address, but are not limited to, the following topics:
– Investigating morphological changes and the pathological basis of drug-induced ototoxicity.
– Explore the biological mechanisms and pathways, including inflammation, immune responses, and cytokine signaling, that contribute to ototoxicity.
– Assess the protective effects and underlying mechanisms of drugs designed to mitigate ototoxicity, identifying new therapeutic targets.
– Review of existing literature on drugs with known ototoxicity-mitigating properties and their mechanisms of action.

Key words: ototoxicity, hearing loss, drug-induced toxicity, aminoglycosides, cisplatin, therapeutic targets, protective agents, hearing health

Important note: All contributions to this research topic must fall within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to refer an out-of-scope manuscript to a more appropriate section or journal at any stage of peer review.