The Bills will have to face the Colts this weekend without one of their top tight ends.

Via multiple reporters, head coach Sean McDermott said in his weekly interview with WGR 550 that rookie Keon Coleman has been ruled out for Week 10 with a wrist injury.

Coleman did not train this week.

The No. 33 pick in this year’s draft, Coleman is currently second on the team with 417 yards receiving. He is tied for the club lead with three receiving touchdowns on 22 catches.

Fellow wide receiver Amari Cooper also dealt with a wrist injury as he missed last Sunday’s win over the Dolphins. But Cooper was limited this week.

The Bills will release their full injury report with game status later Friday.